I am a professor of biostatistics at the Erasmus Medical Center Rotterdam. My research focuses on joint models for longitudinal and time-to-event data with applications in biomarker identification, precision medicine, screening and active surveilance. I currently serve as a co-Editor for Biostatistics [twitter handle].
PhD in Biostatistics, 2008
Katholieke Universiteit Leuven
MSc in Statistics, 2004
Athens University of Economics and Business
BSc in Statistics, 2002
Athens University of Economics and Business
Extensions of joint models for improving subject-specific predictions.
Computational methods for multivariate joint models.
Novel methods for optimally planning when to collect longitudinal measurements or event information.
The current composition of my research group:
Sara Baart: Sara is a post-Doc student working on extending joint models in studies with special types of designs, and in particular in case-cohort designs.
Nicole Erler: Nicole is a post-Doc student working on methods for analyzing longitudinal outcomes with missing baseline and time-varying covariates. She currently also writes an R package for implementing a full Bayesian anlysis in such settings under the sequential approach. More info on her GitHub page.
[GitHub]
[twitter]
Grigorios Papageorgiou: Greg is a post-Doc student working on adapting joint models to incorporate time-varying interventions during follow-up and assess their performance.
[webpage]
[GitHub]
[twitter]
Anja Ruten-Budde: Anja is a post-Doc student working on combinations of joint models with machine learning techniques.
Pedro Manuel Miranda Afonso: Pedro is a PhD student working on extensions of joint models for recurrent event data and spatial correlations with applications in cystic fibrosis.
Aglina Lika: Aglina is a PhD student working in developing methodology and software for Bayesian multivariate mixed effects models.
Floor van Oudenhoven: Floor is a PhD student working in novel applications and methodology of joint models in clinical trials. Her motivation comes from Alzheimer’s disease.
Teun Petersen: Teun is a PhD student working in developing new methods for personalized screening with applications in cardiology.
Hongchao Qi: Hongchao is a PhD student working on extensions of power priors methodology in lonigitudinal clinical trials.
Zhenwei Yang: Zhenwei is a PhD student working on applications of joint models in personalized scheduling with applications in prostate cancer research.
The major R packages I have developed and currently maintain
JMbayes2: Extended Joint Models for Longitudinal and Time-to-Event Data
[GitHub]
[CRAN]
[website]
GLMMadaptive: Generalized Linear Mixed Models using Adaptive Gaussian Quadrature
[GitHub]
[CRAN]
[website]
JMbayes: Joint Models for longitudinal and time-to-event data under a Bayesian approach
[GitHub]
[CRAN]
[JSS paper]
[multivatiate joint Models vignette]
[dynamic predictions vignette]
JM: Joint models for longitudinal and time-to-event data under maximum likelihood
[GitHub]
[CRAN]
[JSS paper]
[Book]
[Book website]
[sample_analysis]
ltm: Latent trait models under the Item Response Theory approach
[GitHub]
[CRAN]
[JSS paper]
[sample_analysis_dichotomous]
[sample_analysis_polytomous1]
[sample_analysis_polytomous2]
[sample_analysis_abilities]
[sample_analysis_information]
cvGEE: Cross-Validated Predictions and Caclulation of Proper Scoring rules for GEE
[GitHub]
[CRAN]
[website]
I am the coordinator for the following courses at Erasmus MC:
CE08: Repeated Measurements
In the GitHub repository a shiny app that replicates all analysis in the course
[course link]
[GitHub]
[slides]
ESP72: Joint Models for Longitudinal and Survival Data
[course link]
[slides]
[solutions_practicals]
EP03: Biostatistical Methods II: Survival Analysis
[course link]
[slides]
[practicals]
[solutions_practicals]
[Survival Analysis in R Companion]
I have been also teaching short-courses in joint modeling in international conferences. A list of recent and upcoming courses
Sun, Dec 20, 2020, Computational and Methodological Statistics
Mon, Nov 16, 2020, CISNET Prostate Annual Meeting
Wed, Aug 26, 2020, ISCB
Tue, Mar 24, 2020, ENAR Spring Meeting
Thu, Jan 23, 2020, Netherlands Cancer Institute Seminar
Wed, Jul 31, 2019, Joint Statistical Meetings
Thu, May 30, 2019, Conference on Lifetime Data Science: Foundations and Frontiers
Thu, Jan 24, 2019, Recent advances in joint models for cancer and the new statistical challenge of immunotherapy clinical studies
Tue, Dec 18, 2018, 10th Conference of the Eastern Mediterranean Region of the International Biometric Society
Thu, Jul 12, 2018, XXVIII International Biometric Conference
I have written the first book on Joint Models for Longitudinal and Survival Data
R-forge website containing the R code to replicate the analysis
A trailer of my inaugural address is available here.
A full list of my publications and grants can be found in my CV.